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impute-gene-expression
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Kevin Kunzmann
impute-gene-expression
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0363752a
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0363752a
authored
Sep 02, 2019
by
Kevin Kunzmann
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bugfix
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599605f5
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0363752a
...
@@ -70,15 +70,13 @@ rule vcf_to_dosages:
...
@@ -70,15 +70,13 @@ rule vcf_to_dosages:
echo "extracting and computing MAFs ..."
echo "extracting and computing MAFs ..."
bcftools +fill-tags {inputs.vcf_gz_file} > $prefix/chr{wildcards.i}.vcf
bcftools +fill-tags {inputs.vcf_gz_file} > $prefix/chr{wildcards.i}.vcf
echo 'querying dosages ...'
echo 'querying dosages ...'
bcftools query -e 'MAF[0]
<{config[min_MAF]} | INFO<
{config[min_INFO]} | TYPE!="snp" | N_ALT!=1' -f '%CHROM %ID %POS %REF %ALT %INFO/MAF [%DS ]\n' $prefix/chr{wildcards.i}.vcf > $prefix/chr{wildcards.i}.dosage.txt
bcftools query -e 'MAF[0]
>{config[min_MAF]} | INFO>
{config[min_INFO]} | TYPE!="snp" | N_ALT!=1' -f '%CHROM %ID %POS %REF %ALT %INFO/MAF [%DS ]\n' $prefix/chr{wildcards.i}.vcf > $prefix/chr{wildcards.i}.dosage.txt
echo 'compressing ...'
echo 'compressing ...'
gzip $prefix/chr{wildcards.i}.dosage.txt
gzip $prefix/chr{wildcards.i}.dosage.txt
rm $prefix/chr{wildcards.i}.vcf
rm $prefix/chr{wildcards.i}.vcf
printf "done.\n\r\n\r"
printf "done.\n\r\n\r"
"""
"""
bcftools query -e 'MAF[0]<0.01 | INFO<{config[min_INFO]} | TYPE!="snp" | N_ALT!=1' -f '%CHROM %ID %POS %REF %ALT %INFO/MAF [%DS ]\n' $prefix/chr{wildcards.i}.vcf > $prefix/chr{wildcards.i}.dosage.txt
# extract sample file for PrediXcan
# extract sample file for PrediXcan
rule generate_samples_file:
rule generate_samples_file:
input:
input:
...
...
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